Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells (IMAGE)
Caption
Figure 1: Distinct expression pattern of KLRG1 on highly differentiated human T cells. (A) Anticorrelated gene expression with PD-1 in RNAseq dataset GSE107011 for differentiated T cell subsets CD4 TEMRA, CD8 TEM, CD8 TEMRA, and γδ T cells. (B) Abstracted previously published data [17] for human blood CD8+ T cells protein surface expression showing increased KLRG1 on effector T memory (TEM) and effector (TEMRA) cells contrasting with decreasing PD-1 on TEMRA. (C–E) Characterization of PD-1+ CD8+ tumor infiltrating lymphocytes (TILS) in non-small cell lung cancer (NSCLC) datasets. (C) Abstracted data from previous publication [20] demonstrating that PD-1-high TILS are not highly differentiated TEMRA (CD27+) and (D) that KLRG1+ TILS are PD-1-. (E) Public domain single cell RNAseq (GSE99531) shows coregulated expression of CTLA-4, TIM-3, LAG-3, and TIGIT but anti-regulated KLRG1 expression in PD-1-high TILS.
Credit
© 2025 Greenberg
Usage Restrictions
With credit to the original source.
License
Original content