Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. (IMAGE)

Maximum Academic Press

Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs.

Caption

Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and transferred into the nucleus, thus reducing Kidins220 expression and inhibiting AMPK phosphorylation.

Credit

Bone Research

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License

CC BY

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