Dextran sulfate sodium-induced colitis exacerbates periodontitis via the NADPH oxidase 2/reactive oxygen species axis in M1-like macrophages (IMAGE)
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In the center, a mouse model of both colitis and periodontitis is depicted on the left, showing the extensive periodontal tissue damage caused by inflammation. On the right, a cluster of macrophages is illustrated, with a focus on the M1-like macrophages highlighted to emphasize their involvement in the inflammatory response. Below, the NOX2/ROS axis is shown as a key signaling pathway that may contribute to the exacerbation of periodontitis. Art by Tiansong Xu.
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