(IMAGE)

Universidad Miguel Hernandez de Elche

Caption

Mesenchymal stromal cells (MSCs) are delivered directly into the lungs using a bronchoscope (CIBA method), where they migrate through the alveolar space and interact with immune cells—such as alveolar macrophages, M1/M2 macrophages and regulatory T cells. This interaction promotes the release of anti-inflammatory signals (like IL-10) and reduces harmful cytokines (such as TNF-α and IL-6), helping to control inflammation in patients on ECMO.

Credit

CIBA Method and the Rationale for MSC Administration. Stem Cell Res Ther. 2025. doi: 10.1186/s13287-025-04289-3

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License

CC BY

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