Figure 1 (IMAGE)

Institute for Basic Science

Figure 1

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Reactive astrocytes in Alzheimer’s Disease uptake and break down amyloid plaques via autophagy, which causes upregulation of the urea cycle and putrescine-to-GABA production. This leads to elevated production of GABA and toxic H2O2, which inhibits neuronal signaling and causes neuronal death (Left). SIRT2 is the last enzyme in the GABA production pathway (Right). Inhibition of SIRT2 reduces GABA, rescuing neuronal inhibition and memory loss, but continues H2O2 production, contributing to neuronal death.

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Institute for Basic Science

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