SIMIP enables high-resolution images rich in both chemical and spatial information. (IMAGE)

SPIE--International Society for Optics and Photonics

SIMIP enables high-resolution images rich in both chemical and spatial information.

Caption

SIMIP enables high-resolution images rich in both chemical and spatial information. A quantum cascade laser (QCL) excites molecular vibrations while a spatial light modulator (SLM) generates striped light patterns that are projected onto the sample. A scientific CMOS (sCMOS) camera captures the modulated fluorescence signals, which are processed using Hessian SIM and sparse deconvolution algorithms to generate high-resolution chemical and structural images. Subtracting the hot image from the cold image yields the hybrid SIMIP image.

Credit

P. Fu, B. Chen, et al., doi 10.1117/1.AP.7.3.036003.

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