DNA methylation entropy is a biomarker for aging (IMAGE)
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Figure 3. Model performance across three methylation metrics and two regression methods. Pearson’s correlation coefficient, equation of best-fit line, and MAE between predicted and chronological age are included. (A–D) Predicted versus chronological age using average methylation, CHALM, entropy, and a combination of these metrics with elastic net regression. (E–H) Predicted versus chronological age with neural network regression.
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Copyright: © 2025 Chan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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