Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury (IMAGE)
Caption
COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ion overload, lipid peroxidation, and excessive oxidative stress. Inhibition of COX-2 has reliable effects in alleviating liver ferroptosis and fibrosis. In future clinical practice, selective COX-2 inhibitors may serve as a potential therapeutic modality to combat liver fibrosis via ferroptosis inhibition
Credit
Huan Tong, Cheng-Wei Tang, Zhu Yang, Yang Tai
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License
CC BY-NC