(IMAGE)
Caption
The fluorescence microscopy images show the nuclei of cultured human cells. On the left, the protein TDP‑43 (green) is seen distributed within the cell nucleus along with nuclear bodies (red), which act as repair sites. When TDP‑43 is damaged by stress or mutations and coupled with SUMO proteins (right image), it is transported to the nucleoli (arrows), where it is protected from aggregation.
Credit
Dr. Jan Keiten-Schmitz
Usage Restrictions
To be used only when reporting on the paper https://doi.org/10.1038/s41589-025-01886-4. Credit: Dr. Jan Keiten-Schmitz
License
Original content