Single-cell RNA-sequencing analysis of normal human testis, paracancerous, and cancer tissues obtained from a patient with testicular DLBCL. (IMAGE)
Caption
(A) Schematic of the experimental design and analysis. Paracancerous and cancer tissues obtained from surgically resected DLBCLs were split and processed for scRNA-seq and spatial transcriptomics. (B) Single-cell expression of all cells from healthy, paracancerous, and testicular DLBCL tissues. The red, blue, and orange colors represent cancerous, healthy, and paracancerous cells, respectively. (C) UMAP plot of cells from Figure 1B. Cell types: germ cells, B cells, Sertoli cells, pericytes, Leydig cells, macrophages, T cells, and endothelial cells. (D) Percentages of different cell types in cancerous, paracancerous, and normal cells. (E) Representative gene expression for each cell type. (F) Immunohistochemical staining of primary testicular DLBCL. (+++) represents high expression; (++) represents mild expression; (+) represents low expression; and (−) represents negative expression.
Credit
Genes & Diseases
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