Evolutionary history of the pandemic Vibrio cholerae lineage (IMAGE)

Universidad Miguel Hernandez de Elche

Evolutionary history of the pandemic Vibrio cholerae lineage

Caption

The evolutionary history of the pandemic Vibrio cholerae lineage shows that its emergence has not been linear, but shaped by several key genetic bottlenecks that explain its rarity. From a group of bacteria with pre-adaptations for virulence (A), new lineages arise with key gene clusters such as CTXΦ or VPI-1 (B), specific modular arrangements within those clusters (C), and unique allelic variations (D). The right combination of all these elements in this genetic mosaic allows the emergence of pathogenic clones from environmental V. cholerae populations (E).

Credit

LĂłpez-PĂ©rez et al. (2025), PNAS, 122(22), e2417915122.

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License

CC BY

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