MPOA-PVN环路在HW和NHW小鼠中的作用机制图 (IMAGE)

Research

MPOA-PVN环路在HW和NHW小鼠中的作用机制图

Caption

A working model of the MPOA-PVN circuit roles in nonhormone withdrawal (NHW) and HW female mice. (A) Based on previous and current findings, MPOA GABAergic neurons project to DR serotonergic neurons or VTA DA neurons via disinhibition of PAGGABA neurons or VTAGABA neurons (previous work) and directly inhibit PVN neurons (current work). PVN neurons may project to PAG/VTA (dashed arrows). Sert, serotonin; Dat, dopamine. (B) Model depicting GABAergic (green) and glutamatergic (red) neurons in the MPOA. Under NHW conditions, elevated activity of MPOA GABAergic neurons (green) may directly inhibit PVNAVP neurons, including AVP-expressing neurons (purple). Conversely, in HW conditions, reduced activity of MPOA GABAergic neurons allows increased activity of PVNAVP neurons, likely involving AVP neurons, which is associated with depressive-like behaviors.

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Copyright © 2025 Ping Fu et al.

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