Transcriptional reprogramming of tumor-infiltrating T cells (TIL) upon cytokine delivery (IMAGE)

Fondazione Telethon

Transcriptional reprogramming of tumor-infiltrating T cells (TIL) upon cytokine delivery

Caption

Left: UMAP projections of CD8⁺/WPRE⁺ (adoptive T cells) and CD8⁺/WPRE⁻ (endogenous T cells) cells mapped onto a reference TIL atlas reveal a reduced prevalence of exhausted CD8⁺ T cells and enrichment of effector/memory phenotypes in the IFNα/oIL2 group. Right: Quantification of T cell subtype composition highlights a shift from terminal exhaustion toward more functional states following combined cytokine treatment.

Credit

San Raffaele-Telethon Institute for Gene Therapy (SR-TIGET)

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