Cognitive performance of PS19 mice injected with CIT or STZ and PBS or AMY. (IMAGE)

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Cognitive performance of PS19 mice injected with CIT or STZ and PBS or AMY.

Caption

(A–D) After the end of treatments, PS19 mice did not present differences in the working memory (Y-maze test) (A) (CIT/PBS, n = 11; STZ/PBS, n = 14; CIT/AMY, n = 10; CIT/AMY, n = 12), recognition memory in novel object recognition test (NOR) (B) (CIT/PBS, n = 11; STZ/PBS, n = 14; CIT/AMY, n = 9; CIT/AMY, n = 14), and spatial memory in the Morris water maze test (MWM) (C, D) (CIT/PBS, n = 10; STZ/PBS, n = 14; CIT/AMY, n = 9; CIT/AMY, n = 13). (E, F) STZ/PBS and STZ/AMY had a better performance in the contextual fear conditioning test (CFC) in comparison with CIT/PBS and CIT/AMY in the training and test sessions (P < 0.05; CIT/PBS, n = 10; STZ/PBS, n = 14; CIT/AMY, n = 9; CIT/AMY, n = 13).

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Genes & Diseases

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