Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity (IMAGE)

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Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity

Caption

LAG-3 exerts its inhibitory function by undergoing phase separation with the CD3ε subunit of the TCR/CD3 complex; Enhancing the cis-proximity between LAG-3 and TCR through a LAG-3/TCR bispecific antibody facilitates the treatment of autoimmune diseases

Credit

LOU Jizhong's group

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