Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience (IMAGE)
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Figure 4: CCDC50 expression is significantly upregulated in BPDCN patients. (A) CCDC50 expression is significantly higher in bone marrow aspirates from BPDCN patients compared to those with AML or CMML (p < 0.0001). Control BM (n = 10): bone marrow aspirates without evidence of hematological malignancy; BPDCN (n = 6): bone marrow aspirates with confirmed BPDCN involvement; Negative BM (n = 10): bone marrow aspirates from patients with a history of BPDCN but without current involvement; AML (n = 10): bone marrow aspirates with AML involvement; CMML (n = 10): bone marrow aspirates with CMML involvement. (B) CCDC50 expression is also significantly elevated in bone marrow clot sections from BPDCN patients (p < 0.0001). Control BM (n = 9): bone marrow clot sections without evidence of hematological malignancy; BPDCN (n = 8): bone marrow clot sections with confirmed BPDCN involvement; Negative BM (n = 5): bone marrow clot sections from patients with a history of BPDCN but without current involvement.
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