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This integrated approach, combining histological analysis and single-nucleus RNA sequencing, revealed that the senescence and depletion of nucleus pulposus progenitor cells (NPPCs) represent fundamental mechanisms shared between lumbar disc (LD) aging and herniation. We identified NFATC2 (encoding the transcription factor NFAT1) as a key pro-senescence regulator that promotes NPPC senescence, potentially driving both age-related disc degeneration and herniation pathology.

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Wang M, He Z, Wang A, Sun S, Li J, Liu F, Li C, Yang C, Lei J, Yu Y, Ma S, Wang S, Zhang W, Yu Z, Liu GH, Qu J

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