Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer (IMAGE)
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Figure 4: Hypoxia reduces the levels of neutral lipids available for peroxidation. (A, B) Volcano plot display significantly altered (Y>1.30, X>1, increase, red dots and Y>1.30, X<-1, decrease, blue dots) lipid species from positive (A) or negative (B) ion mode non-targeted lipidomic analysis. Heat maps represent hierarchical cluster analysis of significant lipids with VIP score >1.5 from non-targeted lipidomic analysis as indicated. PC3 cells were maintained in normoxia (Nor) or hypoxia (Hyp) for 8 h and analysis performed Nor vs. Hyp, n = 3. (C) Histograms showing significantly altered lipid classes (PE and DG) in PC3 cells in hypoxia for 8 h. n = 3, mean ± standard deviation (SD) *P < 0.05 by Student’s t-test.
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