Main Steps (IMAGE)

Shanghai Jiao Tong University Journal Center

Main Steps

Caption

Key steps of 1C metabolism

DHFR: dihydrofolate reductase; FH2: dihydrofolic acid; FH4: tetrahydrofolic acid; MTHFD: methylenetetrahydrofolate dehydrogenase; SHMT: hydroxymethyltransferase; MTHFR: methylenetetrahydrofolate reductase; NADPH: nicotinamide adenine dinucleotide phosphate; 5-mTHF: 5-methyltetrahydrofolat; MTR: N5-methyltetrahydrofolate-homocysteine methyltransferase (methionine synthase); AHCY: adenosylhomocysteinase; BHMT: betaine-homocysteine methyltransferase; Hcy: homocysteine; SAM: S-adenosyl methionine; SAH: S-adenosylhomocysteine; DMG: dimethylglycine; CSE: cystathionine γ-lyase; CBS: cystathionine β-synthase; TCA: tricarboxylic acid cycle.

Credit

Lin Deng, Yu-chan Huang-fu, Yan-hui Ma.

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