The scheme of using integrative multimodal approaches to dissect the cellular and molecular mechanisms regulating wound healing and liver regeneration in ALF. (IMAGE)

First Hospital of Jilin University

The scheme of using integrative multimodal approaches to dissect the cellular and molecular mechanisms regulating wound healing and liver regeneration in ALF.

Caption

(A) Distinct phases of APAP-ALF. (B) Integrative multimodal approaches, including single-nucleus RNA sequencing spatial transcriptomics, four-dimensional intravital imaging and lineage tracing in both human and experimental mouse models of ALF, have led to the identification of a unique subpopulation of hepatocytes that express ANXA2. Although it is currently unclear whether ANXA2-positive cells also express SOX9, this subpopulation of hepatocytes may play a critical role in limiting and closing necrotic areas, potentially aiding in liver repair and regeneration to improve outcomes in ALF. ALF, acute liver failue; APAP, acetaminophen; CV, central vein; CYP2E1, Cytochrome P450 family 2 subfamily E member 1; NAPQI, N-acetyl-p-benzoquinone imine; SOX9, SRY-box transcription factor 9.

Credit

By Khue Nguyen, Wen-Xing Ding, Hong-Min Ni

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CC BY-NC

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