Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines (IMAGE)

Shanghai Jiao Tong University Journal Center

Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines

Caption

  • We report the use of acupoint delivery of nanovaccines (NVs) to elicit a dual-niche immunological priming by simultaneously stimulating mast cell-assisted maturation of CD11b+ dendritic cells (DCs) at the acupoint and directly enriching NVs into the draining lymph nodes (dLNs).
  • The dual-niche immunological priming not only provokes antigen presentation by LN-resident CD8α+ DCs, but also induces the accumulation of NVs in B-cell zones, highlights a facile yet versatile platform for advanced nanovaccination toward tumor therapy and infection prevention.

Credit

Lu Wang, Yanhong Sun, Meiling Yan, Lihua Wang, Yiyang Wang, Mengmeng Zhang, Qian Li, Huangan Wu, Jinyao Liu, Chunhai Fan.

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License

CC BY-NC-ND

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