Water-soluble egg yolk hydrolysate shows osteoclastogenesis inhibitory effects (IMAGE)

Tsinghua University Press

Water-soluble egg yolk hydrolysate shows osteoclastogenesis inhibitory effects

Caption

Three water-soluble egg yolk fractions (FA, FB, and FC) and subfractions of FC (FC1 (< 3 kDa) and FC2 (> 3 kDa)) showed promising osteoclastogenesis inhibitory effects by suppressing osteoclast differentiation in receptor activator of nuclear factor-κB ligand (RANKL)-induced RAW264.7 macrophages. Furthermore, they inhibited RANKL-induced activation of mitogen-activated protein kinase (MAPK) pathway mediators and production of key osteoclastogenic markers in a dose-dependent manner. The FC1 fraction exhibited stronger inhibitory activity on osteoclastogenesis than the FC2 fraction.

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Food Science of Animal Products, Tsinghua University Press

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