G9a-mediated H3K9me2 protects centromere integrity (IMAGE)

Science China Press

G9a-mediated H3K9me2 protects centromere integrity

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Mechanistic model for G9a-H3K9me2 in preserving centromere integrity. G9a-mediated H3K9me2 at centromeres prevents the invasion of H3K9me3 into core centromeric domains, which ensures proper centromeric transcription, R-loop formation, and RPA loading, eventually facilitating the activation of the ATR-Chk1-Aurora B cascade and faithful chromosome segregation.

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