Figure 1. Fear-memory extinction and remote fear-memory responses are regulated by the activity of basal amygdala excitatory neurons (IMAGE)
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In normal mice, after a traumatic event, the synaptic network complex and excitability of basal amygdala excitatory neurons increase, which activates the basal amygdala, facilitating the extinction of fear-memory and preventing remote fear-memory responses (left). However, in Grin2b mutant autistic mice, the synaptic network complex and excitability of basal amygdala excitatory neurons do not increase after a traumatic event, suppressing the activation of the basal amygdala, hindering the extinction of fear-memory, and resulting in enhanced remote fear-memory responses (middle). When the basal amygdala is artificially activated during the extinction process of fear-memory, the synaptic network complex and excitability of basal amygdala excitatory neurons increase, resulting in the rescue of fear-memory extinction and alleviating remote fear-memory responses (right).
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