Core-shell structured light-converting microneedle patch for the treatment of psoriasis lesions (IMAGE)

Tsinghua University Press

Core-shell structured light-converting microneedle patch for the treatment of psoriasis lesions

Caption

A light-converting microneedle patch (EU-MN) delivers targeted intradermal UV phototherapy by releasing upconversion nanoparticles (UCNPs) and the photosensitizer MOP in response to skin conditions, activated by external NIR irradiation. Additionally, the reactive oxygen species (ROS)-responsive microneedle shell releases epigallocatechin gallate (EGCG) for sustained anti-inflammatory effects, thereby minimizing UV-induced damage and enhancing therapeutic efficacy, as demonstrated in psoriasis treatment.

Credit

Nano Research, Tsinghua University Press

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