In vivo PET imaging and biodistribution of radiolabeled EV and antibody fragments in xenograft models of TNBC. (IMAGE)
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Figure 2: In vivo PET imaging and biodistribution of radiolabeled EV and antibody fragments in xenograft models of TNBC. (A) Representative PET images of mice bearing MDA-MB-468, BT474, and MDA-MB-231 tumors at 1, 4, 12, 24, and 48-h after injection of [64Cu]Cu-NOTA-EV or [64Cu]Cu-NOTA-EV-F(ab′)2, with or without blocking. Tumors are indicated by white arrows. (B) Quantitative biodistribution data (%ID/g) of radiotracers in tumor and major organs over time. (C) T/H and T/M ratios over time as determined by region-of-interest image analyses. T/NT = tumor to nontumor.
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Image courtesy of Wenpeng Huang, et al., University of Wisconsin–Madison and Peking University First Hospital.
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