Schematic summary of the astrocyte‐to‐endothelial angiotensinogen (AGT) signaling hypothesis. (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

Schematic summary of the astrocyte‐to‐endothelial angiotensinogen (AGT) signaling hypothesis.

Caption

Increased expression of the Ang‐II (Angiotensin II) precursor AGT in aged astrocytes lead to increased Ang‐II signaling from aged astrocytes to endothelium, thus increasingblood–brain barrier (BBB) permeability and leakiness.

Credit

Professor Eng H. Lo from Massachusetts General Hospital and Harvard Medical School Image source link: https://onlinelibrary.wiley.com/doi/10.1002/nep3.70013

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CC BY-NC

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