Fig. 1 (IMAGE)

The University of Osaka

Fig. 1

Caption

Loss of preTfr during COVID-19 correlates with autoantibody production. A) preTfr cells differentiate into mature Tfr cells, which secrete IL-1RA to suppress plasma cell formation and antibody production. B) During severe COVID-19 infection, preTfr cell frequencies decline over time (red line), while anti-cytokine autoantibody levels increase (green line), suggesting loss of preTfr contributes to dysregulated autoantibody production. Image created in Biorender.com.

Credit

Tulyeu et al. Science Advances, 2025, licensed under CC BY

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