Genotoxic stress and melanocyte stem cell fate (IMAGE)

The Institute of Medical Science, The University of Tokyo

Genotoxic stress and melanocyte stem cell fate

Caption

Genotoxic insults drive divergent outcomes in melanocyte stem cells (McSCs). Under cytotoxic genotoxin exposure, such as X-ray irradiation, McSC self-renewal is impaired, leading to depletion and hair graying. In homeostasis, McSCs maintain self-renewal and pigment balance. Carcinogenic genotoxins, however, promote KIT signaling and alter arachidonic acid metabolism, giving rise to melanoma founder clones and progression to melanoma.

Credit

Emi K. Nishimura from The University of Tokyo, Japan

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