Widespread folate receptor expression in pediatric and adolescent solid tumors - opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine (IMAGE)
Caption
Figure 1: Panel of various pediatric tumors comparing H&E staining, FRα, and FRβ protein expression within the tumor. None of these tumors demonstrate FRα expression; however all of the tumors demonstrate moderate to strong FRβ expression (brown staining). Row 1: Ewing Sarcoma in a pulmonary metastatic lesion of a 20-year-old. Row 2: Primary Synovial Sarcoma in a 17-year-old. Row 3: Osteosarcoma in a pulmonary metastatic lesion of a 15-year-old. Row 4: Primary Wilms tumor in a 7-year-old. Row 5: Primary Rhabdomyosarcoma (RMS) in a 2-year-old. H&E slides at 10x magnification. FRα and FRβ stained slides at 20x magnification.
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Copyright: © 2025 Dodd et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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