Summary of This Study (IMAGE)

National Institutes of Natural Sciences

Summary of This Study

Caption

2DG-induced glucoprivation promotes high-carbohydrate diet (HCD) and high-fat diet (HFD) intakes in the paraventricular nucleus of the hypothalamus (PVH) by activating neuropeptide Y (NPY) neurons in the nucleus of the solitary tract (NTS), ventrolateral medulla (VLM), and the arcuate nucleus of the hypothalamus (ARC). Activation of NPY neurons in the NTS and VLM stimulates AMPK-regulated corticotropin-releasing hormone (CRH) neurons in the PVH, leading to increased HCD intake that helps offset the impaired glucose metabolism caused by 2DG. In contrast, PVH-projecting NPY neurons in the NTS, VLM, and ARC, which also release AgRP (agouti-related peptide), increase HFD intake after 2DG injection by inhibiting PVH melanocortin 4 receptor (MC4R) neurons.

Credit

Yasuhiko Minokoshi

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