Single-cell multi-omics reveals tumor heterogeneity and microenvironment interactions in BTCs. (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Single-cell multi-omics reveals tumor heterogeneity and microenvironment interactions in BTCs.

Caption

The diagram highlights: clonal tumor populations comprising multiple molecular subtypes, contributing to BTCs heterogeneity. Distinct TME components, including: cancer-associated fibroblasts (CAFs) differentiated into: myoCAFs (promoting angiogenesis via HGF and TGF-β signaling); iCAFs (secreting inflammatory cytokines such as IL-6 and VEGFA); Immune cells involved in inflammatory response

Credit

Nannan Tang （Renji Hospital, Shanghai Jiao Tong University School of Medicine）

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