Physiological effects of astringent flavanols (FLs). (IMAGE)

Shibaura Institute of Technology

Physiological effects of astringent flavanols (FLs).

Caption

A single oral administration of astringent FLs stimulated the central nervous system, activating the hypothalamic coricotropin-releasing hormone (CRH) neurons. The secreted CRH activated the noradrenaline (NA) neural network in the locus coeruleus (LC). The projection of NA from LC to the hypothalamus preoptic area suppresses sleep and promotes wakefulness. The projection of NA and dopamine (DA) from LC and DA from the ventral tegmental area to the hippocampus enhances memory. The projection of NA from LC to the brainstem activates sympathetic nerve activity, augmenting circulation and metabolism.

Credit

Dr. Yasuyuki Fujii from Shibaura Institute of Technology, Japan Source Link: https://www.sciencedirect.com/science/article/pii/S2665927125002266

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