The metastatic cascade of BCBrM (IMAGE)

Sichuan International Medical Exchange and Promotion Association

The metastatic cascade of BCBrM

Caption

Tumor cells from the primary lesion undergo EMT and invade the bloodstream. Once in the circulatory system, these CTCs enter a dormant state to evade immune surveillance. Dormant tumor cells are transported to the brain via blood circulation, where they penetrate the BBB and undergo MET. Following this, tumor cells remodel the brain microenvironment and establish co‐colonization with various brain cells, ultimately leading to the formation of BCBrM.

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Suling Liu

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