St. Jude scientists uncovered Exportin-1 (EXPO1)’s role in UBTF-TD AML, revealing a new therapeutic target for high-risk pediatric leukemia (IMAGE)

St. Jude Children's Research Hospital

St. Jude scientists uncovered Exportin-1 (EXPO1)’s role in UBTF-TD AML, revealing a new therapeutic target for high-risk pediatric leukemia

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Published today in Blood Cancer Discovery, research from co-corresponding authors Jeffery Klco, MD, PhD, St. Jude Department of Pathology, and Richard Kriwacki, PhD, St. Jude Department of Structural Biology, and led by co-first authors Juan Barajas, PhD, St. Jude Department of Pathology (pictured, right), and Aaron Philips, PhD, St. Jude Department of Structural Biology (pictured, left), reveal how tandem duplications in the UBTF gene give rise to an abnormal transport signal in UBTF-TD AML, uncovering a promising new therapeutic strategy for this high-risk pediatric cancer.

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Courtesy of St. Jude Children's Research Hospital

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