Fig. 1 Nanomechanical measurement of a living cell nucleus by Nanoendoscopy-AFM. (IMAGE)

Nano Life Science Institute (NanoLSI), Kanazawa University

Fig. 1 Nanomechanical measurement of a living cell nucleus by Nanoendoscopy-AFM.

Caption

(a) A scanning electron microscope (SEM) image of the nanoneedle probe used for the measurements. (b) Elasticity map of a 1 µm × 1 µm area on the nuclear surface, showing the change in elasticity before (Control) and after treatment with TGF-β. (c) Schematic illustration of the measurement, where the nanoneedle probe is inserted into a living cell to directly indent the nucleus and measure its elasticity. (d) A typical force-distance curve showing the force increase corresponding to the indentation of the cell membrane and the nuclear envelope.

Credit

Adapted from ACS Appl. Nano Mater., 2025. (DOI: 10.1021/acsanm.5c03044). Licensed under CC-BY 4.0.

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.