The coffee paradox in adenosine-mediated antidepressant action. (IMAGE)

Genomic Press

The coffee paradox in adenosine-mediated antidepressant action.

Caption

The coffee paradox in adenosine-mediated antidepressant action. Depression (left) and coffee consumption (right) are both linked through adenosine signaling (center), creating a pharmacological paradox: chronic coffee drinking appears protective against depression through tonic adenosine receptor
modulation, while acute pre-treatment caffeine may attenuate the phasic adenosine surge required for rapid antidepressant responses to ketamine and electroconvulsive therapy.

Credit

Julio Licinio

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CC BY

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