Graphical summary illustrating how ELOVL5 regulates both metabolic and immune arms of resolution (IMAGE)
Caption
In IAV-infected wild-type AECII, ELOVL5 promoted inflammation resolution and cell proliferation through both regulating lipid metabolism (promoting PUFAs generation while decreasing eicosanoid levels) and inhibiting STING-TBK1 signaling. Deficiency of Elovl5 increased eicosanoid levels and STING-TBK1 signaling, by which increased interferon and inflammatory cytokine expressions and consequently impaired inflammation resolution and tissue repair.
Credit
Professor Xuetao Cao from Chinese Academy of Medical Sciences, Beijing 100005, China Image source link: https://link.springer.com/article/10.1007/s44466-025-00013-1
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