Artificial Cell Derived Vesicles from Ginsenoside Rg1-Primed Mesenchymal Stromal Cells Mitigate Oxidative Stress and DNA Damage in Myocardial Ischemic/Reperfusion Injury (IMAGE)

Tsinghua University Press

Artificial Cell Derived Vesicles from Ginsenoside Rg1-Primed Mesenchymal Stromal Cells Mitigate Oxidative Stress and DNA Damage in Myocardial Ischemic/Reperfusion Injury

Caption

Mesenchymal stromal cells (MSCs) were cultured on microcarriers in 3D rotating bioreactors and primed with ginsenoside Rg1 to enhance cell proliferation. Artificial cell-derived vesicles (ACDVs) from Rg1-primed MSCs were generated via polycarbonate membrane extrusion and showed superior efficacy in treating myocardial ischemia/reperfusion injury (MI/RI) through intramyocardial injection. With reduced oxidative stress and DNA damage, Rg1-ACDVs exemplify the synergy between bioactive phytochemicals with nanoscale engineering strategies, offering a novel and scalable MI/RI therapy.

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Nano Research, Tsinghua University Press

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