The metal-ion-chelating PTEN mRNA biomimetic delivery system for precise cancer immunotherapy. (IMAGE)

Science China Press

The metal-ion-chelating PTEN mRNA biomimetic delivery system for precise cancer immunotherapy.

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Mn2+ assembles with PTEN mRNA through weak forces rather than electrostatic interactions, facilitating reversible and efficient cellular mRNA release with a rational absolute binding free energies and dissociation constant. Through αPD-L1-modified monocyte-macrophage membrane coating, Mn-NP@PM achieves tumor targeting and utilizes membrane fusion for direct cytoplasmic mRNA delivery and optimizing transportation efficiency.

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