Preparation and tumor inhibition mechanism of HMC nanoparticles. (IMAGE)

Beijing Institute of Technology Press Co., Ltd

Preparation and tumor inhibition mechanism of HMC nanoparticles.

Caption

 (A) Schematic of HMC preparation using SiO₂@ZIF-8 as a sacrificial template through calcination and etching. (B) Transmission electron microscopy image showing HMC's hollow structure with surface channels. (C) Mechanism of sono-immunotherapy: HMC accumulates in tumors, generates ROS under ultrasound to induce immunogenic cell death, releases immune factors, activates dendritic cells, and promotes T cell-mediated tumor elimination. (D) In vivo therapeutic effect: HMC combined with PD-L1 inhibitor effectively inhibits the growth of transplanted and in situ pancreatic tumors.

Credit

Libin Chen, Liaoning Cancer Hospital & Institute; Haiwei Li, The First Affiliated Hospital of Ningbo University

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.