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Research Organization of Information and Systems

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The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated MCM helicase, thereby determining where DNA replication initiates (left). Activation of the MCM helicase then leads to the formation of replication forks (right).

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© The Kanemaki laboratory at National Institute of Genetics

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