IL-17 Mediates the Impact of Porphyromonas gingivalis on Periapical Inflammation and Systemic Metabolic Dysfunction (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

IL-17 Mediates the Impact of Porphyromonas gingivalis on Periapical Inflammation and Systemic Metabolic Dysfunction

Caption

Schematic overview showing how Porphyromonas gingivalis (Pg) with intact LPS drives periapical bone loss and systemic glucose intolerance through IL-17–mediated inflammation. Pg colonization in teeth induces immune cell infiltration (CD45, CD19, Th17) and adipose tissue inflammation, worsening glucose metabolism in high-fat diet mice. These effects are reduced in mice infected with LPS-deficient Pg or lacking IL-17, highlighting IL-17’s key role in linking oral infection to metabolic dysfunction.

Credit

Vincent Blasco-Baque from INSERM/Université de Toulouse/CHU of Toulouse Image link: https://doi.org/10.1038/s41368-025-00403-6

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