Inhibition of MCM helicase activity by CDT1 (IMAGE)

Toho University

Inhibition of MCM helicase activity by CDT1

Caption

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, potentially causing genomic instability.

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Dr.Shusuke Tada

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