Figure 1 (IMAGE)

The University of Hong Kong

Figure 1

Caption

Figure 1. ANKLE1 senses mechanical tension in DNA and helps resolve DNA bridges connecting separating daughter nuclei. ANKLE1 (green) localises to the midbody (red) during cell division. In cells lacking ANKLE1, DNA bridges become elongated and remain unresolved. Using magnetic tweezers, applying tension to DNA induces cleavage by ANKLE1, demonstrating its tension-dependent DNA cutting activity. Image adapted from Jiang et al, Nature Communications (2025).

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The University of Hong Kong

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