Genome-wide profiling of chromatin accessible regions (IMAGE)

The Institute of Medical Science, The University of Tokyo

Genome-wide profiling of chromatin accessible regions

Caption

Genome-wide chromatin accessibility profiling reveals how myelodysplastic syndrome (MDS) stem cells progressively lose normal stem-cell features and acquire myeloid progenitor-like characteristics. These chromatin shifts help map the molecular trajectory of disease progression and form the basis of a chromatin-derived “progenitor score” that reflects MDS severity.

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Professor Atsushi Iwama from The Institute of Medical Science, The University of Tokyo, Japan

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