B Cells Transiently Unlock Their Plasticity, Risking Lymphoma Development (IMAGE)
Caption
The illustration depicts how during differentiation cells normally lose their plasticity and ability to acquire new fates. However, when fully differentiated B cells (naive B cells) initiate an immune response called germinal center reaction, they transiently regain plasticity under the control of T cell helper cells. This plasticity is rapidly lost again under normal conditions as cells become antibody producing plasma cells or memory B cells.
Credit
Dr. Effie Apostolou and Dr. Laurianne Scourzic
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