Fig. (IMAGE)

The University of Osaka

Fig.

Caption

In cells, CENP-A binds to histone H4 and HJURP before it is incorporated into the centromere. The previous model proposed that HJURP recognizes Mis18C and CENP-A is incorporated into the centromere during the G1 phase (Mis18C pathway). However, Hori et al. found that CENP-A is still incorporated even when the Mis18C pathway is inhibited. This suggests the existence of an additional pathway for CENP-A incorporation. Further analysis revealed that the CENP-A-H4-HJURP complex recognizes another centromere protein, CENP-C, and CENP-A is incorporated into the centromere (CENP-C pathway). Simultaneous inhibition of both pathways completely abolished CENP-A incorporation, resulting in cell death due to abnormal mitosis.

Credit

2026, Tetsuya Hori et al., Dual pathways via CENP-C and Mis18C recruit HJURP for CENP-A deposition into vertebrate centromeres, EMBO Journal

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