Microglia Promote Neurodegeneration and Hyperkatifeia during Withdrawal and Abstinence from Binge Alcohol (IMAGE)

Elsevier

Microglia Promote Neurodegeneration and Hyperkatifeia during Withdrawal and Abstinence from Binge Alcohol

Caption

New research in The American Journal of Pathology has identified neuroinflammation, driven by microglia (immune cells), as a primary underlying driver of prolonged negative feelings (hyperkatifeia) caused by repeated, sustained cycles of binge drinking. EtOH: ethanol; BDNF: Brain-Derived Neurotrophic Factor (protein); BNST: Bed Nucleus of the Stria Terminalis (region); OFC: Orbitofrontal Cortex.

Credit

The American Journal of Pathology / McNair et al.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.

License

CC BY-NC-ND

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.