Activation of the histamine H3 receptor (IMAGE)
Caption
The histamine H3 receptor typically becomes active upon binding to one of its agonists, such as histamine itself. This, in turn, gives way to intracellular interactions with compounds known as trimeric G proteins, triggering downstream signaling effects. However, some mutations in the histamine H3 receptor can render it continuously active, even in the absence of an agonist. Understanding how these mutations affect receptor activity, and their implications in disease, is an important area of study within medicine and biochemistry.
Credit
Professor Mitsunori Shiroishi from Tokyo University of Science, Japan
Usage Restrictions
Cannot be reused.
License
Original content